Clusterin is a key molecule that improves IPAD

Japan Society of Science fellowship – £140,000

Genome-wide association studies of sporadic Alzheimer’s disease have demonstrated variations in the gene encoding clusterin, a disulfide linked heterodimeric glycoprotein. Experimental work suggests that clusterin plays a major role in the clearance of Aβ42 via low density lipoprotein-related protein 2. In this project we aim to demonstrate that Clusterin is a key molecule that improves IPAD by testing the following hypothesis:

1. The absence of clusterin results in a failure of IPAD
2. Recombinant clusterin improves IPAD
3. The absence of clusterin results in structural alterations of IPAD