Noradrenergic regulation of amyloid clearance in AD

BrightFocus Foundation (USA) collaboration with Michigan State University

In this project we will test the extent to which noradrenergic locus coeruleus (LC) and cholinergic basal forebrain (CBF) projection system degeneration contributes to the progression of AD by disrupting the clearance of amyloid-β (Aβ) peptides from the brain via the IPAD pathway.

Other Projects

test
Anhydrase Inhibitors to treat Alzheimer’s Disease
Noradrenergic regulation of amyloid clearance in AD
The link between locus coeruleus degeneration and IPAD
Innervation of cerebral arteries is key to maintenance of IPAD
Failure of IPAD in vascular dementia
Immunisation Strategies for Synucleinopathies
Clusterin is a key molecule that improves IPAD
TUBE: Transport Derived Ultrafines and their Brain Effects
The link between Amyloid-beta and alpha-Synuclein pathology